Madonna unveiled the wild video for her new Maluma-assisted single “Medellín” on Wednesday (April 24) in a live international event hosted by MTV.

The cinematic clip opens with Madonna-as-Madame X kneeling before an altar, gently lit by a gold-and-blue stained glass window. “Dear God, how could I trust anyone after years of disappointment and betrayal?” she whispers in urgent prayer. “How could I not want to run away again and again? Escape. I will never be what society expects me to be.”